Harvard’s George M. Whitesides has the highest Hirsch index of any living chemist, which makes him arguably the most significant in the world. The Hirsch or h-index is a kind of weighted score based on a numerical analysis of a scientist’s published work which factors in both the number of papers and the number of citations those papers receive by other authors.
Back in October of 2008, Whitesides, et. al. published a paper in the Royal Society of Chemistry’s journal Lab on a Chip that describes a technique for separating blood plasma for use in various immunoassays using a piece of plastic tubing taped to an eggbeater. The method can replace a $400 bench centrifuge for many purposes.