First replicating life from artificial DNA reported

Potentially historic news, awaiting replication by the scientific community, from famous biochemistry entrepreneur J. Craig Venter (Wikipedia). From the abstract, published today in AAAS Science, of what may someday prove to be one of the most important papers in ths history of biochemistry:

We report the design, synthesis, and assembly of the 1.08-Mbp Mycoplasma mycoides JCVI-syn1.0 genome starting from digitized genome sequence information and its transplantation into a Mycoplasma capricolum recipient cell to create new Mycoplasma mycoides cells that are controlled only by the synthetic chromosome. The only DNA in the cells is the designed synthetic DNA sequence, including “watermark” sequences and other designed gene deletions and polymorphisms, and mutations acquired during the building process. The new cells have expected phenotypic properties and are capable of continuous self-replication.

The original cell was not completely “synthetic,” but its DNA was. So this is not quite the ultimate realization of the project of organic chemistry, i.e. to create living matter from completely lifeless matter, but it is a giant step in that direction. [via Boing Boing]


I am descended from 5,000 generations of tool-using primates. Also, I went to college and stuff. I am a long-time contributor to MAKE magazine and My work has also appeared in ReadyMade, c't – Magazin für Computertechnik, and The Wall Street Journal.

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