 
 Lawrence Berkeley National Labโalong with USAID’s Global Development Lab, The Lemelson Foundation, The Schmidt Family Foundation, Dalberg Global Development Advisors, The Good Company and OMGโhas put together a list of challenges primed for Makers to solve. They call these “Top 50 Game-Changing Technologies for Defeating Global Poverty.” These are summarized in a 20-page list, and then fully explored in the full 600-page report. They shared this list “because the problems we all seek to address require urgent action,” and they invite the problem-solvers of the world (you, dear readers!) to “begin the conversation.”
The top challenge?
The single most needed breakthrough is a cost-effective, energy-efficient method for desalinating water. โWater will be the defining problem of the next 50 years,โ [Shashi] Buluswar [director of LIGTT, Lawrence Berkeley National Laboratoryโs Institute for Globally Transformative Technologies] said. โItโs probably the single most important thing that needs to be solved.โ

- Global health
- Food security and agricultural development
- Education
- Human rights
- Gender equity
- Water
- Access to electricity
- Digital inclusion
- Resilience against climate change and environmental damage
Take a look at how you can help save the worldโespecially the bolded items that have Makers’ names written all over them! (But really, I could have bolded the whole list.)
Add a comment below if there’s a challenge you would have added to this list that you don’t see!
- Energy-efficient desalination
- Vaccine forย HIV/AIDS.
- Vaccine forย Malaria.
- Vaccine forย TB.
- Smart electronic textbooks
- Biometric ID systems
- Affordable smartphones
- New generation of homes for the poor
- New fertilizer production systems
- Utility-in-a-box for solar mini-grids
- Short-course TB treatment
- Microbicides for HIV / HPV
- Long-lasting antiretroviral for HIV
- PrEP antiretrovirals for HIV prevention
- Complete cure for malaria
- Long-lasting chemical mosquito repellent
- Non-chemical spatial mosquito repellent/attractant
- Clinic-in-a-box
- Oxygen concentrator
- Automated multiplex immunoassays
- Point-of-care nucleic acid diagnostics
- Fully integrated diagnostic panels
- Off-grid vaccine refrigerator
- Thermo-stabilizing mechanism for vaccines
- Nutrient-dense infant weaning foods
- Off-grid refrigerator for households and farmers
- Low-cost refrigerated vehicle
- Precision agriculture systems for irrigation and fertilizer
- Low-cost shallow water drilling system
- Solar-powered irrigation pumps
- Herbicides for weeds
- Low-cost tilling machine
- Alternative to liquid nitrogen for preserving animal semen
- High-nutrient animal fodder
- Portable toolkit of extension workers and veterinarians
- Spatial on-farm pest repellent
- New seed varieties tolerant to drought and heat
- Wearable cameras
- Low-cost aerial vehicles for imagery
- DNA-based rape kit
- Wireless broadband technologies
- IoT for low-income populations
- Sustainable aquaculture systems
- Affordable homes resilient to extreme climate events
- Retrofit filter for vehicle exhaust
- Distributed sensors for environmental toxins
- Low-cost PV minigrid installation
- New generation of low-cost, energy efficient appliances
- New bulk storage technologies
- Mini-grid management solutions
- Low-cost family transport
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